On my system, it runs with wine and a USB to serial adapter and the FoxiOsz program (originally for WinXP), by Michael Butschkau, to be found here: http://www.mikrocontroller.net/topic/167705. Thanks and Kudos to Michael for this! The site offers 3 versions, just get the latest one (v1.1 at the time of writing).
You probably have to tell wine to use /dev/ttyUSB0 (or whichever number) as COM1 (or whichever number) and make sure that your humble userness has the right to access it: Make yourself member of the group “dialout” and add a symbolic link in ~/.wine/dosdevices:
ln -s /dev/ttyUSB0 com1 (or whatever)
If in doubt where your USB2Serial device might show up, you may check it with “ls /dev/ttyUSB*”.